Treatment
Glutathione Vitamin Therapy
Glutathione Vitamin Therapy
Glutathione is a potent antioxidant and a crucial molecule for various bodily functions. It protects against free radicals, aids in toxin removal, and is vital for overall health. Glutathione’s ability to rebuild itself and other antioxidants makes it a key player in health. Declining glutathione levels with age and external stressors can lead to vulnerability to diseases.
Glutathione and Longevity: Centenarians have higher levels of glutathione reductase, linking it to long-term survival.
Glutathione’s role in longevity has been known to the scientific community since 1998.
Glutathione Supplementation: Challenges in creating efficient glutathione supplements due to its size and instability. IV or IM injections of glutathione are safe and effective for short-term treatment. Lack of information on naturally boosting glutathione levels.
Free Radicals and Antioxidants: Explanation of how free radicals, generated in the body, can cause oxidative damage. Antioxidants, including glutathione, neutralise free radicals and prevent oxidative stress. Glutathione’s role in recycling other antioxidants and maintaining balance in the body.
Oxidative Stress: Oxidative stress results from an imbalance between free radicals and antioxidants. Oxidative stress can damage lipids, proteins, and DNA, contributing to various diseases.
Body Detoxification: Glutathione plays a key role in the body’s detoxification process, especially in the liver. Collaboration with other antioxidants like vitamins C, E, A, lipoic acid, and CoQ10.
Glutathione Reserves and Aging: Glutathione levels decline with age, while the body’s demand for it increases. Factors like medication, processed foods, and alcohol consumption affect glutathione demand.
Inflammation: Inflammation is a normal immune response to injury, but chronic inflammation can lead to various health issues.
Chronic inflammation may result from the body’s inability to eliminate harmful substances or regulate the immune response.
Leaky Gut Syndrome: Leaky gut syndrome, or increased intestinal permeability, while not classified as an autoimmune disease, is associated with autoimmune conditions. This condition involves the small intestine’s lining becoming permeable, allowing undigested particles to enter the bloodstream, triggering inflammation, pain, and contributing to autoimmune diseases. Low glutathione levels increase susceptibility to leaky gut, emphasising the importance of supporting GSH levels for prevention and management.
Role of Low Glutathione and Obesity: Declining glutathione production with age may contribute to weight gain, as GSH is crucial for mitochondrial fat burning. A 2013 Baylor University study revealed that inhibiting glutathione synthesis in mice reduced fat burning, emphasising GSH’s role in metabolism. In elderly participants, boosting glutathione levels through supplementation enhanced fat burning and reduced diabetes risk factors, showcasing the potential benefits of maintaining optimal GSH levels for weight management.
Glutathione and Liver Disease:
The liver, a vital detoxification organ, faces challenges from viral infections, drug/alcohol abuse, and inherited diseases. Hepatitis, an inflammatory liver condition, can lead to severe consequences if untreated. Glutathione plays a significant role in mitigating liver damage, as demonstrated by studies in China where glutathione reduced inflammation and improved liver function in hepatitis B patients. Low GSH levels are also linked to non-alcoholic fatty liver disease (NAFLD), and glutathione supplementation shows promise in modifying factors contributing to NAFLD progression.
Macular Degeneration and Cataracts: Glutathione’s antioxidant properties are crucial in protecting the eyes from macular degeneration, where the retina degenerates, leading to vision loss. Age-related conditions like cataracts, caused by oxidative stress, can also benefit from glutathione. Studies suggest that glutathione-boosting compounds and foods may prevent and alleviate these eye disorders.
Slowing Down the Aging Process: Oxidative stress and inflammation contribute to ageing, and glutathione, as a potent antioxidant, helps combat these factors. While ageing is influenced by various factors, maintaining optimal glutathione levels may contribute to graceful ageing. Glutathione’s role in telomere function further connects it to ageing, with studies indicating that healthy lifestyle behaviours, including glutathione support, impact telomere length.
Rejuvenating Skin: Extrinsic and intrinsic ageing impact the skin, causing wrinkles, sagging, and reduced cell turnover. Glutathione protects against UV damage, inhibits tyrosinase activity, and contributes to collagen synthesis, making it valuable in skincare. Glutathione-based products, when effectively formulated, show promise in improving skin elasticity, reducing wrinkles, and lightening age spots.
Sunburn, Bruising, and Scars: Glutathione aids in healing sunburns, bruises, and scars by neutralising free radicals produced during skin damage. It accelerates the healing process, making it beneficial in cosmetic treatments, laser burns, and post-surgical care.
Skin Diseases: Low glutathione levels are associated with various skin diseases, including psoriasis. GSH’s detoxifying role and its impact on immune cells suggest that supplementation or topical application may alleviate symptoms of skin diseases. In conclusion, maintaining optimal glutathione levels proves essential for overall health, addressing various conditions, and supporting the body’s defence against oxidative stress and inflammation.
Acne: Acne is a skin condition encompassing blackheads, whiteheads, and pimples, resulting from blocked pores filled with a combination of sebum and dead skin cells. Inflammation, often due to bacterial involvement, leads to the formation of pus-filled bumps. Immune system response generates free radicals, exacerbating inflammation. In papulopustular acne, studies suggest a potential deficiency in the antioxidant defence system, particularly glutathione. Lower glutathione levels have been associated with various types of acne.
Reducing Toxin Exposure: Living with toxins in our system is a reality, as environmental pollutants surround us. Despite the body’s natural detoxification abilities, widespread exposure to pollutants poses challenges. Researchers estimate exposure to 129 pollutants on a daily basis. Common sources include household items, personal care products, and environmental factors. Glutathione levels play a crucial role in detoxification, emphasising the importance of maintaining optimal levels.
Chemicals Are Everywhere: Over 80,000 hazardous chemicals are in use, present in everyday items such as furniture, cleaning products, cosmetics, and clothing. Eight common pollutants, including Bisphenol-A and Phthalates, can be harmful, affecting hormones and increasing cancer risks. Being an informed consumer, avoiding specific products, and increasing natural glutathione levels become essential strategies to combat toxin exposure.
Heavy Metals: Heavy metals like arsenic, cadmium, and mercury are omnipresent and non-biodegradable. Industrial activities contribute to their presence in air, water, and soil. Fish, fruit juices, plants, and medicines may contain heavy metals, posing health risks. These metals contribute to oxidative stress, requiring efficient detoxification mechanisms, including optimal glutathione levels.
Toxins Formed by the Body: Metabolic processes in the body produce waste materials, including toxic by-products.
Biotransformation determines the creation of safe or harmful metabolites. Glutathione aids in transforming harmful substances into water-soluble molecules for elimination. Cruciferous vegetables support healthy biotransformation.
Medication: While medication is essential, some drugs may have inherent toxicity. Glutathione assists the body in metabolising medicines, reducing the risk of side effects. Maintaining adequate glutathione levels ensures optimal detoxification during medication use.
The Role of the Liver: The liver, a vital organ, serves as the body’s primary filter, metabolising and eliminating toxins. Glutathione plays a central role in the liver’s detoxification process, neutralising pollutants and facilitating their elimination. Understanding the liver’s natural detoxification function emphasises the importance of maintaining glutathione levels.
Glutathione’s Other Roles: Beyond liver detoxification, glutathione neutralises carcinogens in the intestines and colon. Depletion of glutathione in the colon is linked to colorectal cancer. Glutathione’s multifaceted role highlights its significance in preventing diseases, including cancer.
Glutathione and Alcohol: Alcohol consumption produces toxic by-products, particularly acetaldehyde. Glutathione facilitates the conversion of acetaldehyde into acetate for elimination. Chronic alcohol consumption depletes lung glutathione levels, increasing susceptibility to respiratory infections. Boosting glutathione before alcohol consumption may mitigate hangover symptoms.
Exercise and Glutathione: Exercise induces oxidative stress, generating free radicals. While excessive oxidative stress can be harmful, moderate exercise promotes endogenous antioxidant production, including glutathione. Regular physical activity enhances glutathione synthesis, contributing to overall health and vitality.
Benefits of Increased Glutathione Levels
Elevated glutathione levels offer numerous benefits, including reduced joint inflammation, strengthened immune system, improved energy, enhanced mental clarity, and faster exercise recovery. Glutathione serves as an anti-allergenic, aids in conditions like Parkinson’s and Alzheimer’s, and contributes to skin health and wound healing.
How to Increase Glutathione Levels
Natural methods, such as a healthy diet rich in sulphur-containing foods, exercise, and avoiding toxin exposure, can enhance glutathione production. Supplementation may be necessary, especially with age, to maintain optimal glutathione levels and support the body’s detoxification processes.
Various forms of glutathione
Glutathione has been the most researched supplements online for the past three years in a row, and there are over 800,000 searches on Amazon each month for different glutathione products. Clearly, many people are interested in trying this antioxidant. Not all delivery systems are created equal. The primary reason for this is because GSH is a large, unstable, and reactive molecule. Because it’s supposed to seek out all of the nasty guys (free radicals) once it gets inside your body, it’s naturally going to be unruly and aggressive. These features, on the other hand, have made producing a stable form of GSH that is readily absorbed by the body one of the greatest challenges in pharmaceutical research. Perhaps it’s because there hasn’t been a good therapeutic, user-friendly delivery system.
Oral supplements: The disadvantage of using oral glutathione supplements is that after the active GSH enters the system, digestive enzymes in the stomach break down and absorb most of it. It’s difficult to say how much glutathione is absorbed, however, some experts believe that only around 15% of the dose reaches the bloodstream. Taking large dosages of oral supplements is ineffective because you would have to take a huge number of milligrams in order for it to work.
IV and IM glutathione, utilised for various purposes, has limited research but anecdotal usage for over twenty-five years. It addresses overall wellness, fatigue, chronic stress, poor nutrition, injury recovery, and disease treatment. IV nutritional support, including glutathione, has been standard since the 1970s. Conditions like Parkinson’s disease, heavy metal detoxification, high triglycerides, type 2 diabetes, viral infections, tuberculosis, and certain skin conditions respond positively to IV glutathione treatment.
Glutathione upper limits
The issue is not frequently getting too much glutathione, but rather receiving insufficient amounts. GSH is a natural metabolite produced by the body and our bodies know how to utilise it. As a result, although glutathione overload has not been extensively researched, it’s improbable. GSH has a limited quantity of use within a specific period of time. It’s like pouring water into an already full glass. The water will simply overflow the sides rather than flowing into the glass. Similarly, if you overindulge in antioxidants by having back-to-back IV or IM treatments, some of that glutathione will go to waste.
Special Warnings & Side Effects
Generally considered to be free of side effects. No untoward side effects nor interactions with oral administration reported even in prolonged use. It is SAFE. Classified as a food supplement not herbal. Made from genetically synthesised molecules. The only reported side- effect is SKIN WHITENING when taken in increased doses. No toxicities have been reported or suspected as being associated with glutathione.
Contraindications
- During some forms of chemotherapy and radiation where antioxidants are contraindicated due to their inhibition of the free radical formation which is an integral part of the therapeutic mechanism.
- Pregnancy or breastfeeding
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